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Gerald B Appel Selected Research

Membranoproliferative Glomerulonephritis (Membranoproliferative Glomerulonephritis, Type II)

1/2022Association of Histologic Parameters with Outcome in C3 Glomerulopathy and Idiopathic Immunoglobulin-Associated Membranoproliferative Glomerulonephritis.
1/2019Kidney Transplantation in C3 Glomerulopathy: A Case Series.
1/2019C3 glomerulopathy - understanding a rare complement-driven renal disease.
9/2016Complement-Mediated Glomerular Diseases: A Tale of 3 Pathways.
2/2014Toward a working definition of C3 glomerulopathy by immunofluorescence.
1/2013Membranoprolferative glomerulonephritis - mechanisms and treatment.
7/2012Pathology after eculizumab in dense deposit disease and C3 GN.
5/2012Eculizumab for dense deposit disease and C3 glomerulonephritis.
3/2011Treatment of nephrotic syndrome with adrenocorticotropic hormone (ACTH) gel.
1/2009Dense deposit disease: clinicopathologic study of 32 pediatric and adult patients.
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Gerald B Appel Research Topics

Disease

25Proteinuria
01/2022 - 07/2001
18Glomerulonephritis
01/2021 - 09/2002
14Lupus Nephritis
01/2021 - 10/2005
14Chronic Kidney Failure (Chronic Renal Failure)
09/2016 - 04/2003
12Membranoproliferative Glomerulonephritis (Membranoproliferative Glomerulonephritis, Type II)
01/2022 - 01/2004
11IGA Glomerulonephritis (IGA Nephropathy)
01/2021 - 03/2011
9Membranous Glomerulonephritis (Membranous Nephropathy)
01/2020 - 05/2010
8Renal Insufficiency (Renal Failure)
01/2022 - 06/2001
8Nephrotic Syndrome (Syndrome, Nephrotic)
11/2016 - 06/2001
7Hypertension (High Blood Pressure)
01/2021 - 07/2001
5Kidney Diseases (Kidney Disease)
01/2022 - 03/2008
4Fibrosis (Cirrhosis)
01/2018 - 04/2003
4Focal Segmental Glomerulosclerosis (Glomerulosclerosis, Focal)
01/2012 - 06/2001
3Body Weight (Weight, Body)
01/2019 - 11/2011
3Type 2 Diabetes Mellitus (MODY)
12/2018 - 05/2003
2Chronic Renal Insufficiency
01/2021 - 12/2018
2Heart Failure
01/2021 - 05/2014
2Hematologic Neoplasms (Hematological Malignancy)
01/2020 - 07/2016
2Diabetic Nephropathies (Diabetic Nephropathy)
12/2015 - 01/2004
2Paraproteinemias (Monoclonal Gammopathy)
07/2014 - 09/2009
2Lipoid Nephrosis (Glomerulonephritis, Minimal Change)
01/2012 - 03/2011
2Systemic Lupus Erythematosus (Libman-Sacks Disease)
03/2011 - 10/2005
2Albuminuria
03/2008 - 02/2008
2Segmental glomerulosclerosis
02/2008 - 12/2002
2Cryoglobulinemia
01/2004 - 09/2002
1Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
01/2021
1Autoimmune Diseases (Autoimmune Disease)
01/2021
1Hereditary Nephritis (Alport Syndrome)
01/2021
1Weight Loss (Weight Reduction)
12/2018
1Thrombotic Thrombocytopenic Purpura
02/2017
1Hemolytic-Uremic Syndrome
02/2017
1Antiphospholipid Syndrome (Antiphospholipid Antibody Syndrome)
02/2017
1Thrombotic Microangiopathies
02/2017
1Atypical Hemolytic Uremic Syndrome
02/2017
1Chronic Disease (Chronic Diseases)
02/2015
1Microscopic Polyangiitis
02/2015
1Vasculitis (Vasculitides)
02/2015
1Granulomatosis with Polyangiitis (Wegener's Granulomatosis)
02/2015
1Anemia
05/2014
1Nephritis
06/2013

Drug/Important Bio-Agent (IBA)

25CreatinineIBA
01/2022 - 06/2001
10Proteins (Proteins, Gene)FDA Link
01/2021 - 06/2001
9Mycophenolic Acid (Cellcept)FDA LinkGeneric
02/2012 - 11/2005
8Immunoglobulin G (IgG)IBA
01/2021 - 01/2004
8Rituximab (Mabthera)FDA Link
01/2019 - 10/2007
7Cyclophosphamide (Cytoxan)FDA LinkGeneric
02/2012 - 10/2003
6Antineutrophil Cytoplasmic Antibodies (ANCA)IBA
01/2021 - 04/2011
6SteroidsIBA
01/2020 - 09/2008
4Immunoglobulins (Immunoglobulin)IBA
01/2022 - 01/2004
4Antigen-Antibody Complex (Immune Complex)IBA
01/2021 - 01/2004
4Angiotensin IIIBA
01/2015 - 05/2003
4Immunoglobulin A (IgA)IBA
02/2014 - 03/2011
3AntibodiesIBA
01/2020 - 02/2008
3Dichlorodiphenyldichloroethane (DDD)IBA
01/2019 - 01/2009
3Complement System Proteins (Complement)IBA
01/2019 - 01/2013
3AngiotensinsIBA
01/2019 - 10/2007
3Angiotensin Receptor AntagonistsIBA
04/2017 - 09/2004
3AldosteroneIBA
05/2014 - 02/2008
3Adrenocorticotropic Hormone (ACTH)FDA Link
12/2013 - 03/2011
3Azathioprine (Imuran)FDA LinkGeneric
06/2013 - 11/2011
3LipidsIBA
03/2008 - 05/2003
2Complement C3 (C3 Complement)IBA
01/2022 - 01/2019
2bardoxolone methylIBA
01/2021 - 12/2018
2Biomarkers (Surrogate Marker)IBA
01/2021 - 09/2016
2Cyclosporine (Ciclosporin)FDA LinkGeneric
01/2019 - 01/2015
2Complement Membrane Attack Complex (Membrane Attack Complex)IBA
01/2018 - 05/2012
2Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA
04/2017 - 05/2014
21,2,3,4,6,7,8-heptachlorodibenzodioxinIBA
07/2014 - 07/2001
2Immunoglobulin M (IgM)IBA
02/2014 - 06/2012
2Adrenal Cortex Hormones (Corticosteroids)IBA
03/2013 - 10/2007
2eculizumabFDA Link
07/2012 - 05/2012
2NPHS2 proteinIBA
09/2008 - 12/2002
2LDL CholesterolIBA
03/2008 - 05/2003
2Losartan (Cozaar)FDA LinkGeneric
03/2008 - 05/2003
2Pamidronate (Aredia)FDA LinkGeneric
03/2003 - 06/2001
1HLA-DQ5 antigenIBA
01/2022
1HLA Antigens (Human Leukocyte Antigens)IBA
01/2022
1HLA-DQ6 antigenIBA
01/2022
1HLA-DR15 antigenIBA
01/2022
1AlbuminsIBA
01/2021
12- benzylidene- 3- (cyclohexylamino)- 2,3- dihydro- 1H- inden- 1- oneIBA
01/2021
1Hydralazine (Apresoline)FDA LinkGeneric
01/2021
1HLA-A3 Antigen (HLA A3 Antigen)IBA
01/2020
1Indicators and Reagents (Reagents)IBA
01/2020
1ParaproteinsIBA
01/2020
1AntigensIBA
01/2020
1Transforming Growth Factor beta (TGF-beta)IBA
01/2018
1Interferon-gamma (Interferon, gamma)IBA
01/2018
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
01/2018
1Shiga Toxin (Shigella Toxin)IBA
02/2017
1LectinsIBA
09/2016
12'- deoxythymidylyl- (3'- 5')- 2'- deoxyadenosine (d(AT))IBA
01/2016
1Abatacept (Orencia)FDA Link
12/2015
1Monoclonal AntibodiesIBA
01/2015
1Proteasome InhibitorsIBA
07/2014
1Bortezomib (Velcade)FDA Link
07/2014

Therapy/Procedure

34Therapeutics
01/2021 - 06/2001
5Kidney Transplantation
01/2021 - 05/2008
2Glycemic Control
12/2018 - 05/2003
1Duration of Therapy
06/2013